Silence of p15 expression by RNAi enhances cisplatin resistance in hepatocellular carcinoma cells
The insensitivity of hepatocellular carcinoma to chemotherapy is associated with alternation in tumor cell cycling.This current study was designed to investigate the impact of p15 ANTI-STRESS silencing on the sensitivity of Human hepatocellular carcinoma HepG2 cells to cisplatin.HepG2/CDDP/1.6 and HepG2/CDDP/2.0 cells were induced by culture with i